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Please stay out of my affairs, my career and my business. This is not for you. If any of this content is your property and your wish for use of this is not granted at this time, please leave the site now.Allogeneic peripheral blood stem cell transplantation in a patient with acute lymphoblastic leukemia, Hodgkin's disease, and breast cancer: a case report and a review of the literature.
The role of peripheral blood stem cell transplantation (PBSCT) in patients with malignancies has been evaluated in several phase II studies. These studies established that allogeneic PBSCT can be performed in patients with malignancies that were resistant to conventional therapies. The patient who is the subject of this report had acute lymphoblastic leukemia, Hodgkin's disease, and breast cancer. The patient was treated with involved-field radiation therapy for the Hodgkin's disease and chemotherapy for acute lymphoblastic leukemia, prior to allogeneic PBSCT. The patient received a conditioning regimen consisting of fludarabine (25 mg/m(2)/d for 3 days), cyclophosphamide (200 mg/kg IV/d for 2 days), and antithymocyte globulin (1 mg/kg IV/d for 4 days). Graft-versus-host disease prophylaxis was started on day -9 with cyclosporine (4 mg/kg daily) and mycophenolate mofetil (25 mg/kg IV every 8 hours). The patient received a first and a second allograft from the HLA-matched sibling donor (MSD). The first allograft occurred on day -9 and the second allograft occurred 4 days later. The patient is disease-free at 21 months post-transplantation. Acute GVHD 0b46394aab
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